Visomitin SKQ1 5ml eye drops [Mitochondria]

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A few years ago a small molecule SkQ1 was synthesized by the group of professor Vladimir P. Skulachev in the Moscow State University. One part of SkQ1 functions as a molecular “tow truck” carrying the other part of the molecule — an extremely active antioxidant plastoquinone — into mitochondria. Both theoretical calculations and experimental results showed that SkQ1 was delivered into the mitochondria in an extremely targeted and efficient manner. The physics of the mitochondrial membrane and the unique properties of SkQ1 direct it into the inner leaflet of the inner mitochondrial membrane with high precision.

The presence of SkQ1 in the mitochondrial membrane enables mitochondria to protect itself from reactive oxygen species (ROS) by breaking the chain reaction of lipid destruction.This ability of the lead molecule to protect cells against oxidative stress is the key to treating patients suffering from various age-related disorders such as cardiovascular diseases, neurodegenerative disorders, and ophthalmic conditions.More than a dozen studies have been conducted and showed SkQ1 effectiveness in such critical therapeutic areas as the following:

• Age-related macular degeneration (AMD)
• Dry eye syndrome (DES)
• Non-infectious uveitis
• Cataract
• Glaucoma

ResearchGate

• Vladimir P. Skulachev
• Max Skulachev

Lomonosov Moscow State University

• Vladimir P. Skulachev
• Max Skulachev
• MSU SKQ1
• MSU Vizomitin

Web of Science ResearcherID

• Vladimir P. Skulachev
• Max Skulachev

YouTube

• Max Skulachev

Additional information

• Mitotech Develops New Method to Prevent Severe COVID-19

Visomitin Reviews / International

• Visomitin eye drops in the therapy of dystrophic changes in the anterior part of the eye.
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For search engines / Science / Mitochondria

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For search engines / Science / Mitochondria

• Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents doi: 10.18632/aging.100404
• Alzheimer’s Disease-Like Pathology in Senescence-Accelerated OXYS Rats can be Partially Retarded with Mitochondria-Targeted Antioxidant SkQ1 DOI: 10.3233/JAD-131034
• Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats doi: 10.18632/aging.100043
• Behavioral Effects Induced by Mitochondria-Targeted Antioxidant SkQ1 in Wistar and Senescence-Accelerated OXYS Rats DOI: 10.3233/JAD-2010–091675
• Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals Doi: 10.1134/S0006297908120043
• SkQ1 Ophthalmic Solution for Dry Eye Treatment:Results of a Phase 2 Safety and Efficacy Clinical Study in the Environment and During Challenge in the Controlled Adverse Environment Mode DOI 10.1007/s12325–015–0274–5
• Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1 doi: 10.18632/aging.101174
• Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice doi: 10.18632/aging.100772
• SkQ1 treatment and food restriction — two ways to retard an aging program of organisms doi: 10.18632/aging.100410
• The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface doi: 10.1007/s40123–018–0158–2
• Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure doi: 10.18632/aging.100636
• Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome doi: 10.1155/2017/9281519
• The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats doi: 10.18632/aging.100493
• Therapeutic Effect of the Mitochondria-Targeted Antioxidant SkQ1 on the Culture Model of Multiple Sclerosis doi: 10.1155/2019/2082561
• Therapeutic Action of the Mitochondria-Targeted Antioxidant SkQ1 on Retinopathy in OXYS Rats Linked with Improvement of VEGF and PEDF Gene Expression doi: 10.1371/journal.pone.0021682
• Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: Protective effects of SkQ1, lithium ions and insulin doi: 10.1016/j.febslet.2008.08.002
• Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis 10.1155/2017/6412682
• In vivo immunoregulatory properties of the novel mitochondria-targeted antioxidant SkQ1 doi: 10.1016/j.molimm.2012.04.010
• Suppression of AMD-Like Pathology by Mitochondria-Targeted Antioxidant SkQ1 Is Associated with a Decrease in the Accumulation of Amyloid β and in mTOR Activity doi: 10.3390/antiox8060177
• Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice doi: 10.1155/2017/6408278
• SkQ1 Suppresses the p38 MAPK Signaling Pathway Involved in Alzheimer’s Disease-Like Pathology in OXYS Rats 10.3390/antiox9080676
• Influence of antioxidant SkQ1 on accumulation of mitochondrial DNA deletions in the hippocampus of senescence-accelerated OXYS rats doi: 10.1134/S0006297915050120
• Antioxidant SkQ1 Alleviates Signs of Alzheimer’s Disease-like Pathology in Old OXYS Rats by Reversing Mitochondrial Deterioration doi: 10.2174/1567205014666170621111033
• Mitochondria-targeted antioxidant SKQ1 protects cornea from oxidative damage induced by ultraviolet irradiation and mechanical injury doi: 10.1186/s12886–018–0996–7
• Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits
• Mitochondria-targeted antioxidant SkQ1 suppresses fibrosarcoma and rhabdomyosarcoma tumour cell growth doi: 10.1080/15384101.2018.1496748
• SkQ1 slows development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats doi: 10.1134/S0006297912060120
• SkQ1 regulates expression of Nrf2, ARE-controlled genes encoding antioxidant enzymes, and their activity in cerebral cortex under oxidative stress doi: 10.1134/S0006297917080090
• Mitochondria-Targeted Plastoquinone Antioxidant SkQ1 Prevents Amyloid-β-Induced Impairment of Long-Term Potentiation in Rat Hippocampal Slices doi: 10.3233/JAD-122428
• Effects of the mitochondria-targeted antioxidant SkQ1 on sexually motivated behavior in male rats doi: 10.1016/j.pbb.2010.05.007
• Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence doi: 10.1134/S0006297908120055
• Influence of SkQ1 on expression of Nrf2 transcription factor gene, ARE-controlled genes of antioxidant enzymes and their activity in rat blood leukocytes doi: 10.1134/S0006297915050107
• Preventive and therapeutic effects of SkQ1-containing Visomitin eye drops against light-induced retinal degeneration doi: 10.1134/S0006297914100113
• Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1 doi: 10.1016/j.mad.2010.06.003
• Ameliorative effects of SkQ1 eye drops on cataractogenesis in senescence-accelerated OXYS rats doi: 10.1007/s00417–014–2806–0
• The mitochondria-targeted antioxidant SkQ1 restores αB-crystallin expression and protects against AMD-like retinopathy in OXYS rats doi: 10.4161/15384101.2014.958393
• The novel mitochondria-targeted antioxidant SkQ1 modulates angiogenesis and inflammatory micromilieu in a murine orthotopic model of pancreatic cancer doi: 10.1002/ijc.30054
• Efficacy of Mitochondrial Antioxidant Plastoquinonyl-decyl-triphenylphosphonium Bromide (SkQ1) in the Rat Model of Autoimmune Arthritis doi: 10.1155/2016/8703645
• Suppression of Alzheimer’s Disease-Like Pathology Progression by Mitochondria-Targeted Antioxidant SkQ1: A Transcriptome Profiling Study doi: 10.1155/2019/3984906
• Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells doi: 10.1134/S0006297908120031